Convivia by Bennu / Raptor Pharmaceuticals Corp. (Page 4 of 4)

Sorry, Aldous, I should've researched fomepizole a little bit more.

Studies have found oral 4-MP to be as effective as the IV infusion. (Oral administration of fomepizole produces similar blood levels as identical intravenous dose; Marraffa et al 2008). I'm just not sure if the compound was prepared in some way to make it safer/more bioavailable.

According to Patent US20080021083 A1 (the supposed Raptor Pharma patent; use Google Patent to search),
"4-Methylpyrazole (4-MP, also known as fomepizole) is commercially available from chemical suppliers, including, for example, Sigma Aldrich (St. Louis, Mo.), and can also be synthesized easily in commercially viable quantities of pharmaceutical grade.

4-MP can be administered alone or in combination with other substances or active agents. In some embodiments, a composition comprising 4-MP and other ingredients, as described below, is administered.

4-MP can be administered according to any technique known to those of skill in the art. In certain embodiments, 4-MP can be delivered transdermally. In preferable embodiments, the subject can self-administer 4-MP to himself or herself. In preferable embodiments, 4-MP can be administered orally. When orally administered, 4-MP can be in a solid form, for example, as in a powder, tablet, capsule and the like, or in a liquid form."

The patent doesn't specify if the 4-MP has been cut with something else, but it doesn't seem like it is. It also recommends taking 1 mg/kg to 4 mg/kg about an hour before alcohol consumption. Since I weigh about 155 lbs or 70 kg, I would take about 140 mg 4-MP, assuming roughly 2 mg/kg.

I guess one can take a small scoop of 4-MP safely, unless this patent is completely wrong or hasn't been tested. I still wouldn't recommend trying it, but a doctor or scientist would definitely be able to give us some good advice on this.

Thanks for bringing this compound to light again. I would discourage buying the compound and trying it for yourself, unless a medical professional, such as your wife, gives you the OK, but I think our cure is waiting right around the corner.

Thanks, and good luck!!

Hey Aldous (again),

I just took another look at the "Oral administration of fomepizole produces similar blood levels as identical intravenous dose" article, and it seems like fomepizole is totally safe for normal, healthy humans to receive both orally and through IV. The article suggests that oral administration of the compound results in similar bioavailability to that of IV dosing, which is huge for potential users who don't have access to IV equipment or just don't like the whole invasive part of it.

Additionally, the World Health Organization also put out the "Application to Include Fomepizole on the WHO Model List of Essential Medicines." The WHO publication has references to tests on normal human test subjects (no ethanol poisoning, renal or hepatic failure) with only mild side effects of dizziness and nausea (probably not on the level on those with Asian glow anyway).

Sounds good to me.

Well, for all those waiting for Convivia, as AldousHuxley pointed out, it's pretty much readily available at the Sigma Aldrich website.

Regarding safety, from "4-Methylpyrazole: a controlled study of safety in healthy human subjects after single, ascending doses." (Jacobsen et al 1988)

Abstract

4-Methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, is a possible future drug for the treatment of methanol and ethylene glycol intoxications and the severe ethanol-disulfiram reaction. Therefore a placebo-controlled, double-blind, single-dose, randomized, sequential, ascending-dose "Phase I study" was performed in healthy volunteers in order to determine the tolerance of 4-MP at dose levels of 10 (n = 4), 20 (n = 4), 50 (n = 4), and 100 mg/kg (n = 3). Along with each dose group, there were two placebos except with the 100 mg/kg group where there was only one placebo.

In the 10 and 20 mg/kg group there were no side-effects in any subject.

At the 50 mg/kg level, three out of four subjects experienced slight to moderate nausea and dizziness from 0 to 2.5 h after dosing. In the 100 mg/kg group all three subjects reported side-effects like nausea, dizziness, and vertigo, that were short-lived in two subjects, but lasted up to 30 h in one subject. The study was stopped after evaluation of the latter subject, so fewer subjects were completed in this last group. Despite these subjective side-effects, there were no significant changes in objective clinical parameters like pulse, blood pressure, body temperature, or blood and urine chemistries.

We conclude that at a single dose of 4-MP (10-20 mg/kg) producing plasma levels within a probable therapeutic range, no side-effects were attributed to 4-MP.

A gram of 4-MP goes for $77 on SigmaAldrich, which might be kinda pricey, especially if you are a heavier guy/gal, but it is very enticing.

Hey CollegeBoy1,

Yeah, man, same here. I'll order some Fomepizole tomorrow from Cayman Chemical. It's only $35 for 500 mg, and $60 for a gram. I'll also be taking it orally. Definitely not IV'ing it, haha.

caymanchem(dot)com/app/template/Product.vm/catalog/17851

I would probably start off with a dose of 10 mg/kg then see if that works out well. If not, 20 mg/kg is the upper limit of the safe zone. If it plain doesn't work at that point, at least we tried. I'm also currently in college and heading into senior year, so this would be sweet if it worked. I wish you the best of luck, man. I know how it feels to try and hide myself at parties if people there don't know that I flush. It sucks.

I found a thread on the Drugs subreddit (lol) about a guy who uses Fomepizole in order to get drunk more efficiently.

reddit(dot)com/r/Drugs/comments/36ewke/why_isnt_fomepizole_more_popular/

Unfortunately, getting drunk on less alcohol is a side effect of the compound since the ethanol is not metabolized as quickly into acetaldehyde. I PM'd him and responded to his thread about his dosage, but no response yet. I will update this thread if I get a reply.

Fomepizole does have some dangerous side effects, such as vertigo and nausea, but only if taken in abnormally high doses, it seems. I would recommend getting a mini spoon set and small digital scale with some weighing papers from Amazon, which should only run you an additional 20 bucks on Amazon, just to make sure you get the dosages as exact as possible.

I have this small digital scale from Amazon, and it's only 7 bucks.

amazon(dot)com/gp/product/B002HEIE0U?psc=1&redirect=true&ref_=oh_aui_detailpage_o03_s00

Again, good luck, and stay safe, man. I'll try and do the same!!

Edit: I'm not sure if hyperlinks are allowed here.

Haha, thanks, Dalmore. That makes it a lot better. I guess you definitely can link here.

What's your take on this? Pushing it too far?

Yeah, you're right, it is pricey. I read your results on the other thread, and that is awesome. Will definitely try that out next.

You can give yourself a company name that's established today...  :-)

It seems like something will never be available for us?? After 8 years searching myself, nothing has really changed at all. Highly dissapointing

Uni Pharma may not be the only source for Convivia type of pill.  Here are couple others, one is in progress and the other may already be selling it to Europe, Asia and Middle East.