Suggestions for new topics (Page 4 of 6)

in my opinion, zantac (ranitidine) works a lot better than pepcid ac, which doesn't really work for me.  I usually get red after 1 beer, but with zantac I can drink a couple in succession and only get pink after about 2 hours.  i've read online that ranitidine and cimetidine (tagamet), but not famotidine (pepcid) inhibit gastric alcohol dehydrogenase, which reduces the amount of acetaldehyde in your body at one time, same as the convivia drug currently being developed.

Here is info on cause and remedy (only lessens, not eliminate) for hangover.

hi,
what a problem this asian flush is. effects so many people around the world. including myself. anyways from back in the days when i used to research cures for this flush i remember reading things about 'red clover'. i think it had some enzyme in it that might help. also i had the thought of taking liver extract. not sure if any of these will help. as never got around to testing them. i dont really drink much now. and have accepted the fact that i cant drink. after 8 yrs of trouble with it. the zantac thing is good and does help. but a combo with something else more natural to make it a more enjoyable experience could be beneficial.  This site is great for us sufferers. not many people know what the flush is like for us. lets hope  a real cure may someday be widely available.

4-methylpyrazole is used for the treatment of methanol poisoning so don't think it is readily available :)

I emailed Ted Daley head of Raptor Pharma to see if there was any new updates on Convivia, they have done a small trial in Hawaii last year with promising results but are not going to further there testing in the US. They are currently looking for a partner in asia to further there trials but he said that at the start of the year too, so nothing has happened this year which is unfortunate. What i don't understand is why something that effects around 50 millon people is not being pushed as there is a huge money market for this product?? I just want to go out and enjoy myself like everybody else :(

I emailed Raptor pointing out that there is another compound called Alda-1 that treats the same condition but works by increasing the activity of ALDH2, and part of his response was-

As you probably already know, there are those who consider treatments for Asian flush to be enabling of alcoholism or, at a minimum, unworthy of biotechnology efforts.  The fairness of those assessments aside, they tend to increase the regulatory hurdles likely to be thrown up by the FDA, particularly with regard to long-term safety.

So there are some people saying that an asian flush cure is unnecessary, because is helps prevent alcoholism, and this increases the amount of time it takes to find a remedy.  It probably would exist right now if it were not for this fact-

it might also be why raptor is trying to do further development in asia, because it might be easier to bring to the market.

Yet raptor have been looking for a research company over in asia to come onboard for this whole year with no offers??

I know you said you have tried all types of alcohol, but different types of alcohol give different types of reaction. I have read the more expensive purer wines/spirits and beers can lessen flush.

I am of European descent and I don't have the ALDH2 deficiency problem.  However, I suffer from serious rosacea.  This condition has similar symptoms as ALDH2.  My face turns tomato-red when I drink any kind of alcohol.  Wine is the worst culprit.  After two bottles of beer, my face goes into a nasty flush.  I can handle vodka and gin a little better for some odd reason.   Bottom line:  I don't look so good when I have a drink in my hand. 

Fortunately, consuming alcohol only gives me bad cosmetic effects (redness, swelling and occasional pimples).  Drinking alcohol has serious health effects in addition to the uncomfortable cosmetic appearance for those with the Asian blush. 

We rosaceans flush to almost everything though:  caffeinated beverages, warm rooms, cold air, spicy foods, foods with high sugar and carbohydrate content, hot showers, excessive anxiety or panic, and of course--alcohol.  Be thankful that you do not have this skin condition.   I have permanent redness on my face and neck area because of the constant daily flushes.  Not to mention, I am a male in my 30s and my face still breaks out like I was 16 all over again.   Rosacea is very prevalent in people with Northern European ancestry (that includes me).   At least 15-20 million Americans have rosacea to some degree.  But I know from my research that a small population of people of Eastern Asian heritage also have symptoms of rosacea.  It wouldn't surprise me if these people confuse rosacea with the ALDH2 problems. 

Rosaceans use various treatment methods:  laser treatments on the skin, antibiotics, anti-pustule skin creams, beta-blockers, anti-allergen medications, anti-hypertension meds, daily sunscreen application, and try to avoid as many flushing triggers as possible. 

Anyway, I sympathize with you guys.   There is nothing "cute" about someone's cheeks burning and turning fire-engine red.  I hope medical science can cure your condition soon.  Who knows, perhaps research in ALDH2 deficiency can lead to promising treatments for rosacea sufferers like me.

This post has been reported as spam and is awaiting review by the moderators.

http://forum.dvdtalk.com/archive/t-567881.html

check it out... looks like GOOD NEWS!!

i'm not understanding the actual "Cure" in this article.  They talk about Nitroglycerin.  Is this a pill?  is it even legal to take?