Hey Guys and Gals,
I'm here through slightly different channels. Researching 4-methylpyrazole/Fomepizole/Antizol for help with ALDH2 Deficiency. Basically means I can't drink anymore. As I'm sure some of you know, the ALD stands for Acetaldehyde, and is both what alcohol gets broken down into, and also an environmental contaminant that people are exposed to daily from loads of different sources.
Anyway, I felt I needed to point out and reiterate what Steph1234 already posted, that being that Convivia is already available in the form of Fomepizole, the main problem being that it's intravenous. So I have two questions for the community.
First, this a relatively simple compound structure as you can see by visiting Pubmed and searching for the compound Fomepizole.
Furthermore, there are about 50 vendors that supply it as can be seen on the same said search. Rather than waiting years for this to become available, or "flying to Tawain to score some" as one of the other members posted, we could just pool together for a buy-in. Or really even just buy it for yourselves, check it out;
I've checked a few different sources and here's an typical price through an online pharmacy for Antizol:
1mg/mL (4 x 1.5mL) 6.00 mL ------$4,921.99-------
Wow, OK....
But I checked Sigma Aldrich through PubMed and here's the price for a Gram of the same stuff.
222569-1G $77.30
That's both doable and a lot more of the same compound. This rapidly brings me to my second question:
While I don't really mind setting my own intravenous line (growing up with folks in the medical field/wife a nurse) are there any chemists or studying scientists out there that can look at this compound and figure out what the effective oral bio availability is?
Thanks, and hope this helps.