Hey guys,
So I can conclude after 60 days of using AF Formula that it did not work for me, even in conjunction with Pepcid AC and NoGlo. Looking at the ingredient list, AF Formula seems to target the brain's responses to acetaldehyde accumulation, rather than targeting the root of the flushing problem.
Although they do not completely eliminate the flush, I will continue to use NoGlo and Pepcid AC because they seem to treat the root of the flush. NoGlo has alpha lipoic acid and NAC, which generate glutathione that binds to acetaldehyde to form harmless byproduct. Pepcid AC, of course, acts as a H2 inhibitor that counteracts inflammation caused by acidity.
Additionally, I've been occasionally using Acetium, which uses a special form of L-cysteine that only becomes active in the digestive tract, where the toxic and flush-inducing acetaldehyde accumulates. This supplement also appears to counteract the flush. And as Dalmore noted a while ago, the antacid and Acetium combo seems to work well. Acetium, however, is the most expensive of the supplements that I've used (except the AF Formula that I've found out doesn't work for me), running at $42 USD for 60 capsules. Not too bad, I guess, if you only take 2-4 capsules on weekend nights.
The next time I go out for drinks, I'll be experimenting with a new stack. As a frustrated, severe flusher who is slowly running out of college party nights, I've decided to cover all of my bases. In addition to 40-60 mg of Pepcid AC, 2 capsules of NoGlo and 2 capsules of Acetium, I'll use 10 mg of cetirizine (commonly known as Zyrtec, an H1 blocker) and 325 mg of aspirin approximately 1 hour before drinking. Cetirizine inhibits the binding of histamine, which causes vasodilation (hence, the rush of blood to the face), to the body's H1 receptors. Aspirin inhibits the release of prostagladins, such as PGE2, that also contribute to flushing. Ibuprofen might work too, in this case.
Be assured that I've taken both aspirin and cetirizine with alcohol before with mixed results and have turned out relatively fine, but these alone only counteract certain pathways of the flush reaction.
If anyone is interested in experimenting with this stack or already has, please comment and let us know about it. Since finals are next week, I'll be out of commission until the end of exams, but I'll keep you all posted on how it works for me. Doubtful it will, but I hope it does.
Take care everyone!