Asian Flush / Asian Blush / Asian Glow Community
Discussion and anecdotes about the Asian Flush/Flush/Glow/Red Face (turning red when drinking alcohol), including using H2 blockers (e.g. Tagamet, Pepsid, Zantac) and other products to combat its effects. Hosted by Eric Cheng on http://echeng.com
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Asian Flush / Asian Blush / Asian Glow Community → Focused Discussion → H2 Blockers (Tagamet, Pepcid, Zantac, Axid)
I encourage you to check us out online
I looked at the website but was wondering about one thing. Why isn't there any mention of Acetaldehyde?
We recently had a testimonial published from a user who makes a reference to using both NoGlo and an antacid at the same time. It can be found at the top of the testimonials page at gonoglo.com.
These are actual users by the way. If anyone else has any NoGlo testimonials they are welcome to upload them to the website and we will send you a discount!
I am a 46 yr old male and have been suffering from Asian Flush for about 10yrs. I don't drink in the week, only at weekends.
If I drink heavily on a Friday I am ok, but if I then drink heavily on the next day then I will eventually come out in the red face/neck and hives/blotches over back, chest and neck. I feel hot, but not sick or unwell.
I believe that because I have drank so much alcohol my body is overloaded and can't process it quickly enough. This can lead to a build up of Acetaldehyde in my bloodstream which is potentially poisonous and can increase cancer risk.
I am looking for some advice as to how I can stop this happening. If I take Pepcid ac does this only stop the flushing or does this also stop the poisonous Acetaldehyde building up in my bloodstream? All answers would be greatly appreciated, thanks
Also worth mentioning that I am British and not of Asian descent
I have been searching the web non stop recently to try and find a cure for Asian Flush ie. to stop the build up of Acetaldehyde in the bloodstream. I have come across RU-21 and have ordered 120 tablets to try. I will report back when I have tried it, but read on as I have copied the following FYI.
A joint study conducted by Russia's top three scientific research institutes has concluded that the supplement pill RU-21 could have a distinct effect on alcohol metabolism, which would help reduce alcohol-related harm to the human body. These findings will be published in the British scientific journal Addiction Biology. RU-21 is an all-natural formula currently marketed in the United States as a dietary supplement.
The test results showed that RU-21 reduces the toxicity of ethyl alcohol by inhibiting the production rate of acetic aldehyde, the main poison of alcohol. "Acetic aldehyde boosts the chances of developing about 60 diseases, including alcoholism, several cancers, liver cirrhosis and neuropsychological disorders, and also contributes to hangover effects, such as headache, nausea, etc" says Vladimir Nuzhny, M.D., Chief of Laboratory of Toxicology at the National Research Center on Addiction of the Russian Ministry of Public Health.
The study was carried out in accordance with the NIAAA (National Institute of Alcohol Abuse and Alcoholism) guidelines. Participating institutions included National Research Center on Addiction of the Russian Ministry of Public Health, Moscow University of Friendship and Russian Scientific Research Institute of Health.
How it Works
When alcohol is consumed, it enters cells and is broken down into acetaldehyde. Acetaldehyde is an extremely toxic compound believed to be responsible for both, most alcohol-related diseases and the addictive process itself.
The reaction is as follows: CH3CH2OH+NAD+® CH3CHO+NADN+H+ (1)
Then an enzyme called aldehyde dehydrogenise 2 (ALDH2) converts the acetaldehyde into acetic acid, which is non-toxic and can be readily used by the body to provide energy, eventually breaking down into water and carbon dioxide. However, the body is only able to metabolize a certain amount of acetaldehyde within a certain period of time regardless of how much alcohol is being consumed. Consequently, alcohol consumption often results in excess acetaldehyde entering blood stream and causing severe damage to the vital organs and functions of the body.
RU-21 balances alcohol metabolism by slowing down the process of ethanol oxidation into acetaldehyde, so less acetaldehyde occurs in the first place, and then speeding up the process of acetaldehyde decomposition into acetic acid and then water and carbon dioxide.
The first task is the slowing down ethanol oxidation into acetaldehyde was accomplished by the inclusion of dextrose (glucose) into the formula. Dextrose rapidly oxidizes in cytosol of liver cells using the same cytosol NAD pool used by ethanol to convert into acetaldehyde, thereby creating a deficit of cytosol NAD needed for the reaction (1) shown above.
Further, the acceleration of decomposition of acetaldehyde and acetic acid into CO2 and H2O and the energizing of mitochondria were accomplished through activation of aerobic oxidation processes in mitochondria by way of introducing substrates (Succinic Acid, Fumaric Acid), which activate the second half-cycle of tricarboxylic acids. Succinate substrate, which is independent of NADN-dehydrogenise prevents acetaldehyde from causing hypoxia, which often results form the accumulation of suboxidized metabolites, and from impeding NADN oxidation in the respiratory chain of cells.
L-Glutamine was added to the formula to speed up the mitochondria-cytosolic malate-aspartate shuttle, which plays key role in the course of acetaldehyde intoxication development. It also speeds up succinate oxidation process (by preventing oxalic and acetic inhibition of succinate dehydrogenase). In addition, it transforms itself into a-ketoglutarate during a rapid oxidation in Crebs cycle. And finally, the proper concentration of L-Glutamine positively influences glutamate and GAMC synapses in the brain, improving coordination and inhibition processes affected by alcohol intoxication.
Ascorbic Acid was added to the formula in order to activate anti-oxidant systems of the central nervous system, liver and hormone-active tissues (affected by hypoxia and acetaldehyde) and to support adrenal gland cortex, which produces anti-stress hormones.RU-21 is manufacture and marketed by Spirit Sciences USA, Inc. a California-based company engaged in the discovery, development, manufacture and marketing of breakthrough pharmaceutical and nutritional products.The company employs over 1,000 people and markets its products in 15 countries in Europe, North America and countries of CIS.
Clinical Trials
were conducted at the Russian Academy of Sciences, Ministry of Public Health of RF, and earlier at laboratory of the Soviet Military Academy of Sciences.The analysis of scientific data obtained from those clinical trials proved that 1,0g to 3,0g of RU-21 (0,5g tablets) introduced before or during alcohol consumption, significantly reduces the risk of alcohol-related diseases as well as mutagenesis (damage to DNA cells) and also prevents alcohol-induced hangover
I have come across RU-21 and have ordered 120 tablets to try. I will report back when I have tried it,
Try these, http://echeng.com/asianblush/viewtopic.php?pid=9#p9
http://echeng.com/asianblush/viewtopic.php?pid=461#p461
I went out last time and i had 2 zantac (or it was 1) and1 full bottle of rewind hangover. That night i was able to consume 2,5 shots and 4 beers without going super red. Only a little bit of pink, but hardly noticable. Didn't feel any neauseua, headache, or any of those other stupid flush symptons
For the ones who don't know what rewind hangover is. "It's a drink that helps you convert the alcohol faster, which is also better for your body.
I went out last time and i had 2 zantac (or it was 1) and1 full bottle of rewind hangover. That night i was able to consume 2,5 shots and 4 beers without going super red. Only a little bit of pink, but hardly noticable. Didn't feel any neauseua, headache, or any of those other stupid flush symptons
Have you tried it without anti-acid? If you have, how did it work?
Jason1992 wrote:I went out last time and i had 2 zantac (or it was 1) and1 full bottle of rewind hangover. That night i was able to consume 2,5 shots and 4 beers without going super red. Only a little bit of pink, but hardly noticable. Didn't feel any neauseua, headache, or any of those other stupid flush symptons
Have you tried it without anti-acid? If you have, how did it work?
nope haven't really tried it yet:D
look what i came across on the internet, a potential future cure:
Alcohol 'Antidote' Could One Day Sober You Up Fast
Jennifer Welsh | Mar. 8, 2013, 2:54 PM | 857 | 1
Too much booze in your blood? In the future, a pill of a special compound could fix you right up. By combining two enzymes in a thin shell, researchers have been able to lower blood alcohol levels in mice.
"The pill acts in a way extremely similar to the way your liver does," study researcher Yunfeng Lu, of the University of California, Los Angeles, said in a statement. The pill isn't ready for humans yet, Lu said, but "with further research, this discovery could be used as a preventative measure or antidote for alcohol intoxication."
Right now the researchers are saying this method could be used to prevent liver injury after heavy alcohol exposure, like when someone's in the hospital, but it's possible that similar technology could be used to stop drunkenness in its tracks when one needs to sober up on the quick.
"Alcohol consumption is a millennium-old feature of human civilization, with unique social functions," the authors write in the article. "However, excessive consumption and abuse of alcohol is associated with a range of organ injuries and social problems."
The treatment uses our body's normal alcohol metabolizing proteins: alcohol oxidase and catalase. They work together to turn a molecule that contains an alcohol into one that is an aldehyde, which doesn't have the intoxicating effects of booze.
In a lab, the enzymes are encased in a special bubble, which keeps them in close contact, the way they would be within liver cells in the body, where we normally metabolize alcohol into non-intoxicating substances. Without the bubble the enzymes don't work as well.
To get the enzymes into the bubble they first attach them to a DNA ladder, in which special conformations of the DNA match up with the shape of the enzymes. This brings them into close contact, and they can then be encased in the nanoparticle bubble. The DNA scaffolding is then removed, and the enzymes are free to work their alcohol-metabolism magic.
"We’ve shown that we can combine these two enzymes in a way to make them stable, and that in animal models the complex is active and reduces BAC and liver damage," study researcher Lu told The Scientist.
The research was published in the journal Nature Nanotechnology on Feb. 17. This enzymes-in-a-bubble approach can be used for other purposes as well, not just for alcohol-metabolizing enzymes, though we think that's a pretty awesome application.
Another cool application for the complexes: The researchers are working to develop a nanocomplex that rids the body of the hormone that causes baldness.
Liu, et. al, Nat. Nano., 2013.
This is the enzyme complex that works to reduce blood alcohol levels and decrease liver damage when mice overdose on alcohol.
When they fed mice a diet of alcohol and this compound, compared to alcohol alone, they saw that the blood alcohol levels were much lower. At 45 minutes after they took the compound in, their blood levels were 10 percent lower and by 90 minutes they were 32 percent lower.
When they injected the compound into already drunk mice, they saw much lower liver injury indicators, and their blood alcohol dropped much quicker.
Liu, et. al, Nat. Nano., 2013.
These tiny bubbles hold alcohol metabolism enzymes
"It’s a very elegant approach to positioning enzymes in a controlled fashion, and it’s certainly a step forward," Jan van Hest, of Radboud University in Holland, who was not involved in the study, told The Scientist. “They show very nice results already, with increased [enzyme] activity in living systems, and it’s a very generic approach so it looks like it could be extended [to other applications].”
The alcoholic substance is passed directly from one enzyme to the other, so the toxic intermediate of alcohol metabolism — hydrogen peroxide — isn't floating free in the body. It's transferred to the second enzyme, called catalase, and broken down into water and oxygen.
In the future, it's possible that popping a pill of these compounds after a night out before bed could mean a quicker recovery, but aldehydes are responsible for hangovers, so it might make your morning a little tougher. When an efficient enzyme is found or created to metabolize aldehydes, they can add that to the mix and essentially create a hangover cure.
look what i came across on the internet, a potential future cure:
Alcohol 'Antidote' Could One Day Sober You Up Fast
Jennifer Welsh | Mar. 8, 2013, 2:54 PM | 857 | 1
I don't think that will help the AF sufferers. AF is due to acetaldehyde which is the first byproduct of alcohol metabolism in our body. Then the second metabolism takes place which converts acetaldehyde into acetate (vinegar) by ALDH2 enzyme but this second step is where the trouble is for AF sufferers due to genetic mutation that produces insufficient amount of ALDH2 enzyme. The result is the build up of acetaldehyde in the body which causes flushing, heart palpitation and nausea because it's toxic.
The above product doesn't sound like it increases ALDH2 enzyme or gets rid of acetaldehyde.
Hi.
I'm a 26 year old male from Norway (not asian, pure scandinavian descent) which have developet a flushing reaction in recent years.
I startet drinkin at 17, but didn't get my first reaction until i was 20-21, but then only a very few times untill i turned 23-4 when it started to escalate. At the age of 25-26 it started to become a regularity rather than an oddity and it slowly started to become a huge concern and source of mild depression and lowered self-esteem. Instead of getting it once in a while, it started to occur almost every time i drank. I consulted my physician about this and we did some tests. He said before the results came in that it might be caused by me developing rosacea (as my grandfather had it) which is a skin disease that causes flushing. However, rosacea flushing can also be caused by eating things like hot food (chili) and other things, but I ONLY flush while drinking alcohol.
After having this problem for about a year I read about antihistamines. I remembered that I had pollen allergy as a kid, but stopped taking my medicine when I turned 20-ish as I no longer had symptoms. I then started to take cetirizne regularly, but it didn't have any effect at all on my flushing. I also read about H2-receptors like rantidine and remembered that my ex gf had a pack of those 300 mg pills (the strongest ones?) because of a peptic ulcers and I tried one of with great, positive effects.
When taking one rantidine approx. 1 hour before drinking my flushing totally disappeared and I could drink as much as I wanted without flushing. After som more experimenting I learned that even the mildest dosage (which doesn't need a prescription) of 75 mg actually did the trick, but I would have to start slowly and not go straight on the booze for it to actually counter it.
My physician however meant that even though I didn't flush, the acetyldehyde that is produced is still dangerous so I got a reference to a skin doctor to do some more tests. I'll have to wait a few more months until my appointment, but I'll try to remember to post back when I get the results and if he has some more tips to prevent this all together for us non-asian flushers.
Anyway, I have one question for you all. What pepcid do you find the most efficient?
but I ONLY flush while drinking alcohol.
the acetyldehyde that is produced is still dangerous so I got a reference to a skin doctor to do some more tests.
Does your heart rate increase a lot and get a headache when you drink alcohol? If not, then it may not be due to your digestive system and acetaldehyde accumulation in the body may not be an issue for you.
I never get headaches and I (still) don't get very hungover afterwards, but if I don't use rantidine my heartrate will spike like crazy when I am about to have, or during a flush reaction. Although I don't get headaches while or after drinking, I do get a "pressing" sensation in the head when flushing, like I can feel my head "pumping" to the beat of my heart.
Another thing came to mind right now and that was that when I consulted my physician a while ago he also said that my vitamin d levels were low (30 something, reference between 50-200) so I had to start taking supplements. I've also read on the internet that people with rosacea could see great improvement in the condition when taking vitamin d supplements, but they also said that they would see positive effects after just a couple of days. I've been taking a fairly high dosage of 2-4000 UI a day for over a month now and haven't seen any improvement at all. The main reason I think that I might have rosacea is becuase my grandfather (on my fathers side) had rhinophyma and had to get his nose fixed. Rhinophyma is most often caused by untreated rosacea, and I strongly suspect that my father has this too, even though neither my mom or dad flushes when drinking.
Hello folks, I discovered this forum many years ago when I first went to college. It's time to give back =]
Stats: Vietnamese male, 5'6, 145 lbs, one beer = tomato face + hives + pulsating heartbeat
I began taking 1x Pepcid AC Max (20mg) when we would drink in college. With just 20mg, my face still gets a little pink, but the other symptoms are completely gone. And this is going from beet red with just one dose. If I take shots, my face gets more pink, and my heart definitely beats faster, but both goes away within 15 minutes.Most nights I can have 6-8 drinks in 3-4 hours, almost no hangover, and never red just pink on the cheeks. I'm really thankful for this.
Several people in this forum take 2 doses / 40mg.. I think that's quite a lot and not worth your heath or building your tolerance. If you need 40mg to stay pink, that's okay. Take only what you need, plus the pink is healthy =] And girls look cute with it.
---------
I went to Europe for work and ran out of Pepcid AC and started panicking. In France they have Pepcidduo and in the UK, Pepcidtwo, but both contains other shit that you don't need/want in your system.
Zantac is more common over here. I went out with my friends tonight and took a huge gamble by taking Zantac for the first time. I had a burger and 2 beers over the span of 2 hours. I would say 75mg Zantac = 10mg Pepcid AC. Note that our body chemistries are completely different, so your results will vary. Slightly pink, no side effects.
Conclusion: Try both, take enough to get rid of the beet red face. A little pink is good, and no one really gives a *!#&$ after they see you a 2nd time. Enjoy alcohol responsibly and wear a condom.
Thanks echeng forums for changing my social life. Let me know if you guys have any questions.
Hi vagrant,
Just wondering how long you took the Zantac or Pepcid before your first drink. I've been reading that 30 mins usually works, so I tried taking 60 mg of Pepcid about 2 hours before my first beer, hoping that they extra time would allow my system to absorb the famotidine, but that didn't work well for me. Would 30 mins be better?
And do you take Zantac in conjunction with Pepcid? Or is it just one or the other? I've read of people taking Claritin with Pepcid, but I'm not sure if that would be effective.
Thanks
I usually take Pepcid 20mg 15 minutes before drinking, usually on an empty stomach. College was a few years back, so I don't find myself in too many situations where I have to take shots.. but 30mg is a must for birthdays/Vegas. Once again, 15 minutes are all I need to maintain slight pinkness.
I usually eat at the same time I start drinking, and it definitely slows down the alcohol. Around 30 minutes in and I can start downing a beer every 15-20 minutes.
The most I've done is 14 drinks while on holiday, from 2PM-2AM, almost one drink per hour. I took 20mg to begin my day, and 10mg around the 9PM mark when I felt like the pepcid wasn't working anymore.
No, I have never experimented with both Zantac & Pepcid. Both works for me at the standard dosage level =]
And please.. I urge you guys to reconsider the effects of going over the recommended dosage. 60mg is a lot! I'm sure there's been extensive discussion on this in the last 45 pages, but too lazy to read.
Maybe I'll try the NoGlo supplement next..
Thanks vagrant.
I will definitely try to shorten the time before taking the antacid and having my first drink.
It could be just my particular case, but NoGlo did nothing for me after a month and a half of continued use for my facial flushing. Just reduced heart rate and nausea, which could be helpful for some, but my face was surely still as red as ever.
The only natural solution for the hangover is water because the problems you experience the next day after consuming alcohol is the result of dehydration. Alcohol makes the kidneys release extra fluid. It is highly recommended to drink enough water before and after consuming alcohol.
Famotidine really works for me, but I still get blood shot eyes......
I usually take 1 pill (20mg) of famotindine 45min-1hr before drinking.
Thinking about taking more like 2 pills to see if it reduces my problem of blood shot eyes.
Does anyone get blood shot eyes after drinking? Not the morning after, but right after the alcohol hits you.
Its really weird to have vampire like eyes after drinking, because all of my friends don't get red eyes even they glow.
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Hey Wesley Chan,
Pepcid still only slightly works for me, but it is serviceable. For the bloodshot eyes, Visine or any other eye drop usually clears mine right up.
How Do H2 Blockers Work?
A cell in the stomach, called a parietal cell, makes acid. These cells, found in the stomach lining, are stimulated in a number of ways to produce acid. One of these methods is histamine. H2 Blockers reduce acid production by blocking signals that tell the stomach to make acid. Their four drugs that work by this mechanism in the United States are Zantac (ranitidine), Pepcid (famotidine), Tagamet (cimetidine) and Axid (nizatidine).
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Asian Flush / Asian Blush / Asian Glow Community → Focused Discussion → H2 Blockers (Tagamet, Pepcid, Zantac, Axid)
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