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Hey guys,

Starting to look for more sources of fomepizole in my free time. Still haven't found a way to have it sent to my dorm room. I'll let you know if I find anything.

Haha, yeah, the "I swear it's just for the Asian glow, not for cooking up drugs in my basement" Inc. Founded 2015.

Yeah, I think that has always been my best bet. I will test that out sometime again this week. Most times, drinking just starts happening around me, and I have no choice but to pop a Pepcid discreetly and stall for 30 minutes at the most. And this usually happens right after my roommates and I come back from dinner.

Thanks a lot, Dalmore. Very glad that you've found a killer combo that works for you! I've never been able to get rid of the flushing with just antacids, though, but I hope that L-Cys/Vit. C will help with the rapid heartbeat, which worries me a lot every time.

Yeah, you're right, it is pricey. I read your results on the other thread, and that is awesome. Will definitely try that out next.

Haha, thanks, Dalmore. That makes it a lot better. I guess you definitely can link here.

What's your take on this? Pushing it too far?

Well, for all those waiting for Convivia, as AldousHuxley pointed out, it's pretty much readily available at the Sigma Aldrich website.

Regarding safety, from "4-Methylpyrazole: a controlled study of safety in healthy human subjects after single, ascending doses." (Jacobsen et al 1988)

Abstract

4-Methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, is a possible future drug for the treatment of methanol and ethylene glycol intoxications and the severe ethanol-disulfiram reaction. Therefore a placebo-controlled, double-blind, single-dose, randomized, sequential, ascending-dose "Phase I study" was performed in healthy volunteers in order to determine the tolerance of 4-MP at dose levels of 10 (n = 4), 20 (n = 4), 50 (n = 4), and 100 mg/kg (n = 3). Along with each dose group, there were two placebos except with the 100 mg/kg group where there was only one placebo.

In the 10 and 20 mg/kg group there were no side-effects in any subject.

At the 50 mg/kg level, three out of four subjects experienced slight to moderate nausea and dizziness from 0 to 2.5 h after dosing. In the 100 mg/kg group all three subjects reported side-effects like nausea, dizziness, and vertigo, that were short-lived in two subjects, but lasted up to 30 h in one subject. The study was stopped after evaluation of the latter subject, so fewer subjects were completed in this last group. Despite these subjective side-effects, there were no significant changes in objective clinical parameters like pulse, blood pressure, body temperature, or blood and urine chemistries.

We conclude that at a single dose of 4-MP (10-20 mg/kg) producing plasma levels within a probable therapeutic range, no side-effects were attributed to 4-MP.

A gram of 4-MP goes for $77 on SigmaAldrich, which might be kinda pricey, especially if you are a heavier guy/gal, but it is very enticing.

Hey Aldous (again),

I just took another look at the "Oral administration of fomepizole produces similar blood levels as identical intravenous dose" article, and it seems like fomepizole is totally safe for normal, healthy humans to receive both orally and through IV. The article suggests that oral administration of the compound results in similar bioavailability to that of IV dosing, which is huge for potential users who don't have access to IV equipment or just don't like the whole invasive part of it.

Additionally, the World Health Organization also put out the "Application to Include Fomepizole on the WHO Model List of Essential Medicines." The WHO publication has references to tests on normal human test subjects (no ethanol poisoning, renal or hepatic failure) with only mild side effects of dizziness and nausea (probably not on the level on those with Asian glow anyway).

Sounds good to me.

Hey Aldous,

I took a look at both fomepizole and Alda-1 on SigmaAldrich and saw the hazard signs in both of their product descriptions. It seems like they will both cause acute organ damage if administered orally.

However, there is also a very recent 2015 scientific paper detailing the effects of Alda-1 on rat plasma.

"For the first time, the preclinical oral and intravenous pharmacokinetics of alda-1 were conducted. Alda-1 was found to be a rapidly absorbed, high clearance and poorly bioavailable compound in rats. Its plasma protein binding was found to be 82–86%." (Tenaja et al 2015; Bioavailability, plasma protein binding and metabolic stability studies of a ALDH2 activator, alda-1, using a validated LC-ESI-MS/MS method in rat plasma)

Despite the test results, Alda-1 seems to be a likely cure for the flush in the near future. I just wish that future was now. I wonder how efficient it is compared to fomepizole.

There also seems to be a 2014 patent from China that claims to have details pertaining to a DIY Alda-1 prep kit for oral administration. Search "Alda-1 oral self-microemulsion preparation and preparation method" or "Patent CN103976952 A." Hopefully, this will be made available internationally sometime soon.

From the patent: "According to the preparation disclosed by the invention, the solubility and the oral bioavailability of Alda-1 are remarkably improved by adopting a self-microemulsion nano technology, and the preparation method is simple and low in cost. Meanwhile, use of organic solvents such as DMSO (Dimethylsulfoxide) is avoided, so that Alda-1 is promoted to convert to clinical application and the safety of long-term application is enhanced."

BTW, what is your favorite Huxley novel? I've only read BNW.

Wow, thanks a lot, Alex575!

Interesting that Zantac works so much better for you! And it's great that you still don't get the flushing after having more than 4 drinks. My flush also results from anything from beer to Everclear. While beer gives me the flush immediately, hard liquor takes a little longer to cause a reaction, and the flush from hard stuff is more intense. I've also found out that taking Pepcid after drinking for some reason doesn't work for me. No correcting of the flush if it's already started happening. It's either knocking the pill down about half an hour before drinking or getting the flush all night. I'll try drinking more water in between drinks to stay hydrated. For a lot of people, this seems to help negate the flush as well.

In addition to Pepcid, the H2 histamine blocker, I've also been taking a generic form of Zyrtec, which I think has been helping stop the flush too, since it blocks the H1 histamine response. Aspirin might help for some, but it hasn't had any added benefits for me.

I might see you around San Fran sometime since I'll be headed there later this summer! Hopefully, I won't be glowing the place up!

Hi sharky,

Thanks for sharing your story and your experiences with AF! Yes, it's pretty cool that we can communicate with a community of AF sufferers and learn from them. I haven't read much about abstaining from food, but it is something that I haven't tried yet. Will do that next time. Have you tried taking Pepcid and abstaining from food?

I'll be studying abroad through my university this fall, and I plan on going to Oktoberfest in Munich as well. If we run into each other, I hope that we won't be able to tell that we are members of this forum, if you catch my drift!!