I have been searching the web non stop recently to try and find a cure for Asian Flush ie. to stop the build up of Acetaldehyde in the bloodstream. I have come across RU-21 and have ordered 120 tablets to try. I will report back when I have tried it, but read on as I have copied the following FYI.
A joint study conducted by Russia's top three scientific research institutes has concluded that the supplement pill RU-21 could have a distinct effect on alcohol metabolism, which would help reduce alcohol-related harm to the human body. These findings will be published in the British scientific journal Addiction Biology. RU-21 is an all-natural formula currently marketed in the United States as a dietary supplement.
The test results showed that RU-21 reduces the toxicity of ethyl alcohol by inhibiting the production rate of acetic aldehyde, the main poison of alcohol. "Acetic aldehyde boosts the chances of developing about 60 diseases, including alcoholism, several cancers, liver cirrhosis and neuropsychological disorders, and also contributes to hangover effects, such as headache, nausea, etc" says Vladimir Nuzhny, M.D., Chief of Laboratory of Toxicology at the National Research Center on Addiction of the Russian Ministry of Public Health.
The study was carried out in accordance with the NIAAA (National Institute of Alcohol Abuse and Alcoholism) guidelines. Participating institutions included National Research Center on Addiction of the Russian Ministry of Public Health, Moscow University of Friendship and Russian Scientific Research Institute of Health.
How it Works
When alcohol is consumed, it enters cells and is broken down into acetaldehyde. Acetaldehyde is an extremely toxic compound believed to be responsible for both, most alcohol-related diseases and the addictive process itself.
The reaction is as follows: CH3CH2OH+NAD+® CH3CHO+NADN+H+ (1)
Then an enzyme called aldehyde dehydrogenise 2 (ALDH2) converts the acetaldehyde into acetic acid, which is non-toxic and can be readily used by the body to provide energy, eventually breaking down into water and carbon dioxide. However, the body is only able to metabolize a certain amount of acetaldehyde within a certain period of time regardless of how much alcohol is being consumed. Consequently, alcohol consumption often results in excess acetaldehyde entering blood stream and causing severe damage to the vital organs and functions of the body.
RU-21 balances alcohol metabolism by slowing down the process of ethanol oxidation into acetaldehyde, so less acetaldehyde occurs in the first place, and then speeding up the process of acetaldehyde decomposition into acetic acid and then water and carbon dioxide.
The first task is the slowing down ethanol oxidation into acetaldehyde was accomplished by the inclusion of dextrose (glucose) into the formula. Dextrose rapidly oxidizes in cytosol of liver cells using the same cytosol NAD pool used by ethanol to convert into acetaldehyde, thereby creating a deficit of cytosol NAD needed for the reaction (1) shown above.
Further, the acceleration of decomposition of acetaldehyde and acetic acid into CO2 and H2O and the energizing of mitochondria were accomplished through activation of aerobic oxidation processes in mitochondria by way of introducing substrates (Succinic Acid, Fumaric Acid), which activate the second half-cycle of tricarboxylic acids. Succinate substrate, which is independent of NADN-dehydrogenise prevents acetaldehyde from causing hypoxia, which often results form the accumulation of suboxidized metabolites, and from impeding NADN oxidation in the respiratory chain of cells.
L-Glutamine was added to the formula to speed up the mitochondria-cytosolic malate-aspartate shuttle, which plays key role in the course of acetaldehyde intoxication development. It also speeds up succinate oxidation process (by preventing oxalic and acetic inhibition of succinate dehydrogenase). In addition, it transforms itself into a-ketoglutarate during a rapid oxidation in Crebs cycle. And finally, the proper concentration of L-Glutamine positively influences glutamate and GAMC synapses in the brain, improving coordination and inhibition processes affected by alcohol intoxication.
Ascorbic Acid was added to the formula in order to activate anti-oxidant systems of the central nervous system, liver and hormone-active tissues (affected by hypoxia and acetaldehyde) and to support adrenal gland cortex, which produces anti-stress hormones.RU-21 is manufacture and marketed by Spirit Sciences USA, Inc. a California-based company engaged in the discovery, development, manufacture and marketing of breakthrough pharmaceutical and nutritional products.The company employs over 1,000 people and markets its products in 15 countries in Europe, North America and countries of CIS.
Clinical Trials
were conducted at the Russian Academy of Sciences, Ministry of Public Health of RF, and earlier at laboratory of the Soviet Military Academy of Sciences.The analysis of scientific data obtained from those clinical trials proved that 1,0g to 3,0g of RU-21 (0,5g tablets) introduced before or during alcohol consumption, significantly reduces the risk of alcohol-related diseases as well as mutagenesis (damage to DNA cells) and also prevents alcohol-induced hangover