1 Reply by takezou

(9 replies, posted in Focused Discussion)

I usually take 1 150mg zantac nowadays when I go out drinking.  I used to take pepcid a/c, but it seems I built up a tollerance for it, (I used to drink 4 nights a week.)  With zantac and pepcid sometimes I get a headache/hangover if I have 3-5 drinks, and sometimes it's completely fine.  I've never paid attention to those 'don't eat this or that type of food' warnings some people post - that may be part of it. 

I wouldn't put a lot of faith in Cheerz - the most impressive thing about them is their advertising force.  If they spent the same amount of money they did on advertising and spamming on forums/blogs/message boards, then they might have a decent project.  I know they say one doctor supports the product, but I seem to recall a time when the phrase "9 out 10 doctors support product X" was the standard.  They don't show any peer-reviewed research about the effectiveness of the ingredients, and they don't have a "free trial."  "Money back guarantee" in this day and age doesn't mean a thing - they offer it because they know you won't take the time to do this.

Sorry for the long rant, but I've been following this stuff for a while and I've seen what works, and what makes money - and a surprising amount of the time they are not the same.

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2 Reply by takezou

(1,275 replies, posted in Focused Discussion)

KMan wrote:
takezou wrote:

He also hypothesizes that the ordinary levels of blood-alcohol for Pepcid A/C mean increased levels of acetaldehyde.

...
Takezou has hypothesized on some effects of the H2 blockers. Unfortunately, I have to say that is just pure speculation. When scientist test something, there is a basis for that test. If we just speculate, there could be a billion different hypotheses.
...

Upon reading your reply, I realize that I had wrongly paraphrased you, an embarrasing and on top of it all, feeling hurting mechanism.  Unfortunately, we won't launch into a flame war, beacause I hereby profusely apologize for my actions.  I also apologize for those who wanted to see a flame war, but not profusely.

What I meant to say is that you suggest that for asian flushers, a night of pepcid ac fun probably comes with the same high level of acetaldehyde that the drinker would have if he drank the same amount without pepcid ac, and also that taking zantac instead of pepcid a/c may mean lower levels of acetaldehyde.

Such evidence would be enough to make me more inclined towards zantac, but with such great savior wannabes as Natifus, I wanted to see more.  Thus my devil's advocations of dream-come-true speculations to prompt you to further solidify your case.  To clarify, the speculation of the best case (if pepcid a/c  should break down acetaldehyde directly to prevent red face,) was not a hypothesis, (which should be an educated guess,) but simply a "please show me another thread of logic that rules out these border cases."

Basically, it wasn't a "I don't believe this guy", but more of a wikipedian "This article does not cite its sources."  I know that this forum is NOT wikipedia, but honestly, with so many people viewing this resource, it has a similar function and carries a similar responsibility.

I think that now that you do cite your sources and use them with improved logic to show the above "zantac may be better" argument, everything is clear.  Good job, and thanks for the work.

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3 Reply by takezou

(1,275 replies, posted in Focused Discussion)

I have been following this thread for a few months.  However, this is my first post.  I am full japanese, 25y/o, 5'11", and weigh 145lbs.  Before Pepcid, I would flush strongly upon the first drink, but usually continued to drink 3 or 4 more, thinking, 'If I am going to look like a clown, I should be able at least to have some fun of my own.'

Since discovering this site, I am grateful to the forum members that my alcohol awareness has gone up.   Yes, 20mg of Pepcid A/C takes most of my social anxieties away, but the recent discussions of acetaldehyde have made me if anything, more conscientious about drinking.  If there is a increased risk of cancer for H2 blocker takers, as it sounds like there may be, I feel that it is important that we all have a forum for discussion, not just to verify the effectiveness of pepcid ac, but also of the consequences.

Yeah, it sucks that I'm not exclusively talking about the 12 shots I can pound in 5 seconds and being a Certified Party Dawg in the spirit of alcohol.   I hate to imagine seven years down the road, if people should start pointing to this forum as the fork in the road that led them to their cancer diagnosis. 

For this reason, it may be a good idea to open up a separate thread for the discussion of acetaldehyde. 

KMan has posted the results of an interesting study on the effects of blood-alcohol levels for the various H2 Blockers out there.  I would be very interested if someone could post a link or a journal name for this study.  He also hypothesizes that the ordinary levels of blood-alcohol for Pepcid A/C mean increased levels of acetaldehyde.  I will say right up front that I know absolutely squat about the real process of alcohol processing.  Still, to be the naive devil's advocate, I'd like to know why he rules out the possibility that a) less alcohol is absorbed into the blood stream, and b) that the increased acetaldehyde is broken down faster somehow by the drug(pepcid)

Thanks and keep up the good work.

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