seejenfly, I've read the discussion on product hunt website about the mention of pill form vs. liquid form.  The liquid form may cause policy issues at typical bars as they don't allow people to bring in "drinks" of their own.  Even though this isn't alcoholic beverage, the sight of it being consumed at a bar could raise red flag from the bar staff or bouncer.  For that matter, pill would be a better form.  Just a thought...

seejenfly wrote:

I launched a crowdfunding campaign on Indiegogo that's doing well and you can pre-order the drink there if you're interested. igg.me/at/beforeelixir

The earliest delivery is May of this year?

seejenfly wrote:

It works by slowing down the metabolism of alcohol and thereby the production of acetaldehyde.

Interesting.  So it's like the liquid form of Convivia.

29

(48 replies, posted in Focused Discussion)

Here is something recent on Alda-1.  http://www.fasebj.org/content/28/1_Supplement/585.9
"We showed that when given together with an ALDH2-specific activator, Alda-1, Alda-89 induced a rapid reduction in blood ethanol and acetaldehyde levels after acute ingestion of ethanol in mice. Importantly, treatment with Alda-1 and Alda-89 also reduced behavioral impairment in both wild-type and ALDH2*2 mice."

steph1234 wrote:

and Uni Pharma appears to have abandoned it.

Oh well.  :-(
Then the next hope is Alda-1.  Who knows how long it will be, if ever...

steph1234 wrote:

Does anyone know what email I can use to reach out to Uni Pharma?

http://www.uni-pharma.com/zxxxenglish.html Click on "news" tab and it shows email address but I'm not sure if it goes to Taiwan account.

bchin2020 wrote:

Haha at this rate, as soon as they release the drug in Taiwan, I'll hop on a plane and fly there to get my hands on some...

Please let us know how it goes if you do.

steph1234 wrote:

Do you happen to know about the status of the drug in the US?

I have no idea.  I can imagine black market taking advantage of this though.

What I've heard so far is, "Raptor has an exclusive license agreement with Uni Pharma Co., a Taiwanese pharmaceutical company. Under this agreement, Uni Pharma has rights to developand commercialize Convivia™ in Taiwan. Raptor expects this to be the first in a franchise of out-licensing transactions to develop Convivia™ throughout Asia."  http://www.raptorpharma.com/pipeline/co … deficiency

The sale of this pill was said to begin this year in Asia (Taiwan maybe?).

35

(48 replies, posted in Focused Discussion)

steph1234 wrote:

^ @Dalmore, this is very very interesting, are you suggesting taking Alpha lipoic acid supplements prior to consumption of alcohol and seeing whether or not it would ameliorate asian flush symptoms?

However, would this increase in aldh2 activity mean that aldh2 activity would have to be present already, as the genetic portion of asian flush means that we don't have the biological and chemical capability of producing the enzyme in the first place?

I tried it but didn't make noticeable difference.  I bought Alpha lipoic acid for different purpose so it's no loss for me.  From what I've read, AF sufferers do have aldh2 enzyme but not enough of it.

36

(48 replies, posted in Focused Discussion)

While I was looking up Alda-1 info, I came across this (http://www.sciencedirect.com/science/ar … 9912000040) in a related article.  Alpha lipoic acid supplements are available in nutrition stores under liver health category.  I haven't heard about its use on alcohol flush symptoms but may be a worth investigation.

evaluategroup(dot)com website shows it to be available in Japan.  Go to their site and do a search on Convivia.

crocop65 wrote:

and the method was simply having a teaspoon of active yeast for every pint you drink.

"Dry active yeast has an enzyme in it called alcohol dehydrogenases (ADH). This enzyme has the ability to break down alcohol their constituent parts of carbon, hydrogen, and oxygen, which is basically what happens when it gets to your liver. By having the yeast already in your stomach, it starts breaking down before it gets to the blood stream."

Any truth to this?

There used to be a thread here on Brewer's Yeast pills but looks like it's been deleted.  Anyway, I tried those pills (available at nutrition stores) but only helped tiny bit.  Practically it has no effect against alcohol flushing.

crocop65 wrote:

So my question is, is this a genuine method, or did I just have a lucky night with the redness?  Can using an asthma inhaler, combined with actively controlling your breathing, actually reduce the redness due to a slower heart rate?

No.  It has to do with digesting process of alcohol and its byproduct called acetaldehyde.  Try Google search on "alcohol flush reaction".

Thanks for the report.  Looking forward to hearing more about it.

primehunta wrote:

So if Convivia or Alda-1 is released to the public does this mean that asian flush is permanently cured?

I would say it's more of "remedied" than "cured".  Curing ALDH2 enzyme deficiency would require altering people's existing DNA without damaging other DNA or organs, which I don't see happening in this century.  :(

Or is it like those other treatments like the AF Formula where you have to take it daily?

From what I've read, during Conviva testing on human, it was taken 30 minutes before drinking.  I would imagine that Alda-1 may be the same way.

Jason1992 wrote:

the product is called "Hythiol-C".

I looked it up and noticed that it's been around for a while.  It's also marketed as skin condition supplement.

I have my doubts on its effectiveness against flushing.  If it is, why would Convivia set up markets in Japan and South Korea?

Their active ingredients show L-Cysteine, vitamin C and vitamin B5, which I happened to have some leftover from previous supplement shopping.  I'll try that combo and see what happens.

For me, it was antacid and Acetium combo.

After trying antacid and AF Reducer combo, I regret to say that it's not as effective as other combos I tried.  Externally, it works well but internally (which I consider more important) it's not helping much.  I won't be buying additional AF Reducer.

Flushing came back little bit but didn't last long.   I was already sober at that point.
For me, 4 caps of Acetium didn't make any difference to 3 caps.

I will in couple days. 

As for AF Reducer's results internally, I don't think it's as effective as Acetium because the heart rate went up sooner than trying Acetium. 

The bottom line is, until Convivia or Alda-1 is available to the public, I don't think there is a solid alternative, unfortunately.

AF Reducer wrote:

Our supplement is taken prior to drinking and significantly reduces flushing caused by alcohol. I encourage you to check us out online at AFreducer.com .

I was skeptical before but decided to try AF Reducer.  It worked little better than other products made for the same purpose.  The instruction says to take 2 to 3 caps 30 minutes before drinking.  I tried 2 and it reduced about 60% of flushing.  Next day I tried 3 caps and it worked little better.  Then the third day, I tried 4 caps and it reduced about 75% of flushing.  That's without using any anti-acid pills.  I would say this is the best one for me so far.

Tried Alcotox.  Just like the others, it only reduces flushing about 50 percent.

I was one of first few buyers of NoGlo.  Perhaps the writings have changed since I ordered it.

coco55 wrote:

"NoGlo® is backed by an unconditional 60-day money back guarantee. If you are not satisfied with NoGlo® for any reason, simply send the bottles back to us, for a full product cost refund."

Only unopened bottles could be returned.  So obviously one has to open the bottle in order to try the product, which means we do not get our refunds back.  Is this correct?  This statement to me is very misleading.

I've tried NoGlo.  I don't remember seeing "only unopened bottle" can be refunded.
On the bottle, it says it will reduce alcohol flushing.  It doesn't say it will eliminate flushing.  For me it worked as described.