Asian Flush / Asian Blush / Asian Glow Community

Re: Alda-1 treatment (research)

2012-05-13T02:54:10Z

obliko wrote:

Any updates on Alda-1??
I came close to buying the raw stuff but then thought twice about self-administering an untested drug...

^^ Good call. Hopefully a tested version will be released soon...

Re: We need a logo! Any volunteers? :)

2012-05-09T13:49:50Z

The other major factor is the fact that change is uncomfortable. Doing what we've learned through training is not easy. What we are currently doing is comfortable to us and easy to stick with because it's what we are used to. Here's the clincher, we stick with it even though we know the better thing we really should be doing.

Re: Alda-1 treatment (research)

2012-05-07T18:17:24Z

Any updates on Alda-1??

I came close to buying the raw stuff but then thought twice about self-administering an untested drug...

Re: Side effects

2012-04-23T12:39:22Z

I dont know if you realize it or not but you can get a generic pepcid for WAAAAAAAAAAAAY cheaper! I am talking about 112 20 mg pills of pepcid for $22. If anyone is interested send me an email and I will send you the link.

Re: Scientific reason for why we turn red

2012-04-23T09:39:00Z

From what I understand Pepcid alone will only reduce facial redness and nothing else. The h2 Blockers slow down the rate at which the alcohol is converted to Acetaldehyde which is why.

Re: We need a logo! Any volunteers? :)

2012-04-23T09:37:21Z

I would glady make a logo for you if you wish

Re: Scientific reason for why we turn red

2012-04-21T18:27:49Z

MTER wrote:

In a way, I'm a little nervous about Alda-1 and being a human beta since it is essentially altering my body to produce a chemical versus just taking the chemical when I need it. I don't think Alda-1 has been used on humans at all...am I missing something?

From what I've read, Alda-1 has not been tested on human (Re: Alda-1 thread on this forum). I would put it little differently about its function. Per article online, it is to support the inadequate liver function of those with ALDH2 deficiency gene to be able to function normally via artificial buttressing of cellular structure that is necessary to metabolize acetaldehyde.

The article also mentions the benefit of this cellular level activity which can allow the effectiveness of heart medications for those with heart problem. The impression I've got from the article/s is that Alda-1 has a greater use than just alcohol related issues which can make its future brighter than Convivia.

Re: H2 Blockers (Tagamet, Pepcid, Zantac, Axid)

2012-04-21T04:13:34Z

^interesting

Re: Scientific reason for why we turn red

2012-04-20T00:53:42Z

Dalmore, Convivia and Alda-1 are similar. Convivia is essentially the missing enzyme in ALDH-2 deficient people that allow them to break down alcohol into acetate instead of letting it remain as acetaldehyde. Alda-1 is, however, "fixing" the malformed gene so that our body can naturally produce was Convivia substitutes.

So yes, it is working slightly different in the way it introduces the enzyme into our body. However, Alda-1 seems a lot further from ever becoming available than Convivia since Convivia is already approved in an intravenous form. In a way, I'm a little nervous about Alda-1 and being a human beta since it is essentially altering my body to produce a chemical versus just taking the chemical when I need it. I don't think Alda-1 has been used on humans at all...am I missing something?

Re: Scientific reason for why we turn red

2012-04-19T22:49:24Z

MTER wrote:

Additionally, if you are focusing your efforts on the stomach, how will this new compound address 2nd-pass alcohol metabolism that is done in the liver?

Good post MTER however, my understanding on Conviva is (correct me if I'm wrong), it neutralizes acetaldehyde in bloodstream. Alda-1 on the other hand, helps the metabolic function of liver of those with ALDH2 deficiency so that it can process acetaldehyde normally.

Re: Scientific reason for why we turn red

2012-04-18T17:28:34Z

Hey Chris, I was wondering where you got the information that Convivia is not viable. I believe they passed Phase 1 and Phase 2 of their clinical trials and my understanding was that they wanted to test the market in Taiwan, hence why it is currently not going through Phase 3 in the states. I don't have a pharmaceutical background but I didn't think we could allow patient trials for stage 1 and stage 2 if there is known harm to patients using the medication.

As for the compound you are working on, I am glad you are taking matters into your own hands and I wish you the best of luck. However, if you are working on an H2 drug, or one that is modeled off of H2 antagonists, how is that different than Pepcid AC? Isn't it doing the same thing in treating the neutralization of acids in the stomach? I didn't think it could neutralize and break down Acetaldehyde which is the dangerous part and the cause of the flushing.

Additionally, if you are focusing your efforts on the stomach, how will this new compound address 2nd-pass alcohol metabolism that is done in the liver?

Re: Scientific reason for why we turn red

2012-04-09T05:12:32Z

Business Venture Opportunity-
I'm a biochemist that has been working for over 3 years to discover a viable business opportunity to create a cure for this affliction. Unfortunately for all of you out there, it doesn't seem like Convivia will ever be an option in a country such as ours with such strict regulations (as well as Japan and China) because the mechanism of action of 4-methylpyrazole, originally used to treat methanol poisoning, is just too dangerous to be taken regularly or sold over the counter. I am also well aware of the misinformation coming from Cheerz and NoRedFaceFormula, which seem to have little to no effect in treating alcohol flush reaction. Finally, Pepcid AC, which seems to be the general go-to cure for most people, most likely blocks the histamine (redness) response but does nothing to reduce acetaldehyde levels, resulting in a greatly increased risk of cancer and liver cirrhosis.
I believe that I have found a potential cure, based both on anecdotal evidence from this forum and personal research, that will prove to cure both the symptoms of Asian glow. I have developed a formulation, based largely on H2 antagonists (blockers) as well as antioxidants which target and neutralize acetaldehyde while protecting the stomach.
I am currently working with the former CFO of Pfizer, Canada, as well as an American teacher in Japan to develop this business, but require someone with an entrepreneurial spirit and experience in the pharmaceutical industry, preferably regulatory experience. Anyone with a PHD or MS in biochemistry or a related field should also contact me at chrisumbach@gmail.com

PS: ECheng - I contacted you via email several times regarding this venture. If you want an effective and harmless cure for this ailment, please help me to recruit for this new venture.

Re: H2 Blockers (Tagamet, Pepcid, Zantac, Axid)

2012-04-09T05:09:47Z

Business Venture Opportunity
I'm a biochemist that has been working for over 3 years to discover a viable business opportunity to create a cure for this affliction. Unfortunately for all of you out there, it doesn't seem like Convivia will ever be an option in a country such as ours with such strict regulations (as well as Japan and China) because the mechanism of action of 4-methylpyrazole, originally used to treat methanol poisoning, is just too dangerous to be taken regularly or sold over the counter. I am also well aware of the misinformation coming from Cheerz and NoRedFaceFormula, which seem to have little to no effect in treating alcohol flush reaction. Finally, Pepcid AC, which seems to be the general go-to cure for most people, most likely blocks the histamine (redness) response but does nothing to reduce acetaldehyde levels, resulting in a greatly increased risk of cancer and liver cirrhosis.
I believe that I have found a potential cure, based both on anecdotal evidence from this forum and personal research, that will prove to cure both the symptoms of Asian glow. I have developed a formulation, based largely on H2 antagonists (blockers) as well as antioxidants which target and neutralize acetaldehyde while protecting the stomach.
I am currently working with the former CFO of Pfizer, Canada, as well as an American teacher in Japan to develop this business, but require someone with an entrepreneurial spirit and experience in the pharmaceutical industry, preferably regulatory experience. Anyone with a PHD or MS in biochemistry or a related field should also contact me at chrisumbach@gmail.com

PS: ECheng - I contacted you via email several times regarding this venture. If you want an effective and harmless cure for this ailment, please help me to recruit for this new venture.

Re: RU-21 -- The Mystery

2012-03-31T06:20:43Z

I’m impressed, I must say. Really seldom do I see a forum that’s both educative and entertaining, and let me tell you, you’ve hit the nail on the head. Your thoughts is important; the issue is something that not a lot of people are talking intelligently about. I’m really happy that I stumbled across this in my search for something relating to this.

Re: has there been any news?

2012-03-29T19:13:55Z

Another given today is a coffee table book or flush mount album. All major wedding photographers offer these books to their clients. Having a photographer that can design these books in house is a benefit to you. Changes you want will be easier to accomplish if your photographer is the designer and not using a 3rd party.